Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 575079, 17 pages
http://dx.doi.org/10.1155/2015/575079
Research Article

Long-Term In Vitro Degradation of a High-Strength Brushite Cement in Water, PBS, and Serum Solution

Division of Applied Materials Science, Department of Engineering Sciences, Uppsala University, Sweden

Received 22 May 2015; Accepted 28 September 2015

Academic Editor: Vladimir S. Komlev

Copyright © 2015 Ingrid Ajaxon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Larsson and T. W. Bauer, “Use of injectable calcium phosphate cement for fracture fixation: a review,” Clinical Orthopaedics and Related Research, no. 395, pp. 23–32, 2002. View at Google Scholar · View at Scopus
  2. F. Tamimi, Z. Sheikh, and J. Barralet, “Dicalcium phosphate cements: brushite and monetite,” Acta Biomaterialia, vol. 8, no. 2, pp. 474–487, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Bohner, “Design of ceramic-based cements and putties for bone graft substitution,” European Cells and Materials, vol. 20, pp. 1–12, 2010. View at Google Scholar · View at Scopus
  4. M. Bohner, “Bioresorbable ceramics,” in Degradation Rate of Bioresorbable Materials: Prediction and Evaluation, F. Buchanan, Ed., pp. 95–114, Woodhead Publishing Limited, Cambridge, UK, 1st edition, 2008. View at Google Scholar
  5. L. M. Grover, J. C. Knowles, G. J. P. Fleming, and J. E. Barralet, “In vitro ageing of brushite calcium phosphate cement,” Biomaterials, vol. 24, no. 23, pp. 4133–4141, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. L. M. Grover, U. Gbureck, A. J. Wright, M. Tremayne, and J. E. Barralet, “Biologically mediated resorption of brushite cement in vitro,” Biomaterials, vol. 27, no. 10, pp. 2178–2185, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. C. de Oliveira Renó, N. C. Pereta, C. A. Bertran, M. Motisuke, and E. de Sousa, “Study of in vitro degradation of brushite cements scaffolds,” Journal of Materials Science: Materials in Medicine, vol. 25, no. 10, pp. 2297–2303, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. D. L. Alge, W. S. Goebel, and T.-M. G. Chu, “Effects of DCPD cement chemistry on degradation properties and cytocompatibility: comparison of MCPM/β-TCP and MCPM/HA formulations,” Biomedical Materials, vol. 8, no. 2, Article ID 025010, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Cama, F. Barberis, M. Capurro, L. Di Silvio, and S. Deb, “Tailoring brushite for in situ setting bone cements,” Materials Chemistry and Physics, vol. 130, no. 3, pp. 1139–1145, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Bohner, H. P. Merkle, and J. Lemaître, “In vitro aging of a calcium phosphate cement,” Journal of Materials Science: Materials in Medicine, vol. 11, no. 3, pp. 155–162, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Unosson and H. Engqvist, “Development of a resorbable calcium phosphate cement with load bearing capacity,” Bioceramics Development and Applications, vol. 4, article 074, 2014. View at Google Scholar
  12. T. R. Blattert, L. Jestaedt, and A. Weckbach, “Suitability of a calcium phosphate cement in osteoporotic vertebral body fracture augmentation: a controlled, randomized, clinical trial of balloon kyphoplasty comparing calcium phosphate versus polymethylmethacrylate,” Spine, vol. 34, no. 2, pp. 108–114, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. I. Ajaxon, Y. Maazouz, M. P. Ginebra, C. Öhman, and C. Persson, “Evaluation of a porosity measurement method for wet calcium phosphate cements,” Journal of Biomaterials Applications, 2015. View at Publisher · View at Google Scholar
  14. D. L. Alge, W. S. Goebel, and T.-M. G. Chu, “In vitro degradation and cytocompatibility of dicalcium phosphate dihydrate cements prepared using the monocalcium phosphate monohydrate/hydroxyapatite system reveals rapid conversion to HA as a key mechanism,” Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 100, no. 3, pp. 595–602, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. Z. Huan and J. Chang, “Novel bioactive composite bone cements based on the β-tricalcium phosphate–monocalcium phosphate monohydrate composite cement system,” Acta Biomaterialia, vol. 5, no. 4, pp. 1253–1264, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. T. A. Einhorn and L. C. Gerstenfeld, “Fracture healing: mechanisms and interventions,” Nature Reviews Rheumatology, vol. 11, no. 1, pp. 45–54, 2014. View at Publisher · View at Google Scholar
  17. U. Lindgren and O. Svensson, Ortopedi. Fjärde Upplagan, Liber AB, Solna, Sweden, 2014.
  18. S. Rousseau and J. Lemaître, “Long-term aging of brushite cements in physiological conditions: an in vitro study,” European Cells and Materials, vol. 5, no. 2, article 83, 2003. View at Google Scholar · View at Scopus
  19. Y. N. Tan, S. Patel, U. Gbureck, and L. M. Grover, “Controlling degradation in calcium phosphate cements,” Advances in Applied Ceramics, vol. 110, no. 8, pp. 457–463, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Unosson, Physical properties of acidic calcium phosphate cements [Ph.D. thesis], Department of Engineering Sciences, Uppsala University, Uppsala, Sweden, 2014.
  21. ASTM International, “Standard specification for acrylic bone cement,” ASTM F 451-08, ASTM International, West Conshohocken, Pa, USA, 2008. View at Google Scholar
  22. ASTM International, “Standard test method for wear testing of polymeric materials used in total joint prostheses,” ASTM F 732-00, ASTM International, West Conshohocken, Pa, USA, 2013. View at Google Scholar
  23. K. K. Aligizaki, Pore Structure of Cement-Based Materials: Testing, Interpretation and Requirements, CRC Press, 2005.
  24. N. Doebelin and R. Kleeberg, “Profex: a graphical user interface for the Rietveld refinement program BGMN,” Journal of Applied Crystallography, vol. 48, no. 5, pp. 1573–1580, 2015. View at Publisher · View at Google Scholar
  25. T. Taut, R. Kleeberg, and J. Bergmann, “Seifert software: the new Seifert Rietveld program BGMN and its application to quantitative phase analysis,” Materials Structure, vol. 5, no. 1, pp. 57–66, 1998. View at Google Scholar
  26. J. Bergmann, P. Friedel, and R. Kleeberg, “BGMN—a new fundamental parameters based rietveld program for laboratory X-ray sources, it's use in quantitative analysis and structure investigations,” IUCr Commission on Powder Diffraction Newsletter, no. 20, pp. 5–8, 1998. View at Google Scholar
  27. ASTM International, “Standard practise for use of the terms precision and bias in ASTM test methods,” ASTM E 177-14, ASTM International, West Conshohocken, Pa, USA, 2013. View at Google Scholar
  28. N. Döbelin, “Interlaboratory study on the quantification of calcium phosphate phases by Rietveld refinement,” Powder Diffraction, vol. 30, no. 3, pp. 231–241, 2015. View at Publisher · View at Google Scholar
  29. B. Dickens, L. W. Schroeder, and W. E. Brown, “Crystallographic studies of the role of Mg as a stabilizing impurity in β-Ca3(PO4)2. The crystal structure of pure β-Ca3(PO4)2,” Journal of Solid State Chemistry, vol. 10, no. 3, pp. 232–248, 1974. View at Publisher · View at Google Scholar · View at Scopus
  30. N. A. Curry and D. W. Jones, “Crystal structure of brushite, calcium hydrogen orthophosphate dihydrate: a neutron-diffraction investigation,” Journal of the Chemical Society A: Inorganic, Physical, and Theoretical Chemistry, pp. 3725–3729, 1971. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Boudin, A. Grandin, M. M. Borel, A. Leclaire, and B. Raveau, “Redetermination of the β-Ca2P2O7 structure,” Acta Crystallographica Section C, vol. 49, pp. 2062–2064, 1993. View at Publisher · View at Google Scholar
  32. B. Dickens, J. S. Bowen, and W. E. Brown, “A refinement of the crystal structure of CaHPO4 (synthetic monetite),” Acta Crystallographica Section B, vol. 28, pp. 797–806, 1971. View at Publisher · View at Google Scholar
  33. M. Mathew, W. E. Brown, L. W. Schroeder, and B. Dickens, “Crystal structure of octacalcium bis(hydrogenphosphate) tetrakis(phosphate)pentahydrate, Ca8(HP04)2(PO4)4·5H2O,” Journal of Crystallographic and Spectroscopic Research, vol. 18, no. 3, pp. 235–250, 1988. View at Publisher · View at Google Scholar
  34. R. W. Rice, “Microstructure dependence of mechanical behaviour of ceramics,” in Treatise on Materials Science and Technology, R. K. McCrone, Ed., pp. 199–381, Academic Press, New York, NY, USA, 1977. View at Google Scholar
  35. J. Engstrand Unosson, C. Persson, and H. Engqvist, “An evaluation of methods to determine the porosity of calcium phosphate cements,” Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 103, no. 1, pp. 62–71, 2015. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Mandel and A. C. Tas, “Brushite (CaHPO4·2H2O) to octacalcium phosphate (Ca8(HPO4)2(PO4)4·5H2O) transformation in DMEM solutions at 36.5 °C,” Materials Science and Engineering C, vol. 30, no. 2, pp. 245–254, 2010. View at Publisher · View at Google Scholar
  37. D. L. Kopperdahl and T. M. Keaveny, “Yield strain behavior of trabecular bone,” Journal of Biomechanics, vol. 31, no. 7, pp. 601–608, 1998. View at Publisher · View at Google Scholar · View at Scopus
  38. E. F. Morgan and T. M. Keaveny, “Dependence of yield strain of human trabecular bone on anatomic site,” Journal of Biomechanics, vol. 34, no. 5, pp. 569–577, 2001. View at Publisher · View at Google Scholar · View at Scopus
  39. E. Perilli, M. Baleani, C. Öhman, R. Fognani, F. Baruffaldi, and M. Viceconti, “Dependence of mechanical compressive strength on local variations in microarchitecture in cancellous bone of proximal human femur,” Journal of Biomechanics, vol. 41, no. 2, pp. 438–446, 2008. View at Publisher · View at Google Scholar · View at Scopus