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BioMed Research International
Volume 2015 (2015), Article ID 576306, 8 pages
http://dx.doi.org/10.1155/2015/576306
Research Article

Glycated Albumin Levels in Patients with Type 2 Diabetes Increase Relative to HbA1c with Time

1Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea
2Severance Hospital, Seoul, Republic of Korea
3Severance Executive Healthcare Clinic, Yonsei University Health System, Seoul, Republic of Korea

Received 25 June 2015; Revised 29 August 2015; Accepted 9 September 2015

Academic Editor: Yoshifumi Saisho

Copyright © 2015 Hye-jin Yoon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We recently reported that glycated albumin (GA) is increased in subjects with longer duration of diabetes and with decreased insulin secretory function. Based on this, we investigated whether GA increases with time relative to glycated hemoglobin () and the association between GA and beta-cell function. We analyzed 340 type 2 diabetes patients whose serum GA and HbA1c levels had been repeatedly measured over 4 years. We assessed the pattern of changes with time in glycemic indices (GA, , and GA/ ratio) and their relationship with beta-cell function. In all patients, glycemic indices decreased and maintained low levels around 15 and 27 months. However, from 39 months to 51 months, GA significantly increased but tended to increase without statistical significance. We defined ΔGA/ as the difference between the nadir point (at 15 to 27 months) and the end point (at 39 to 51 months) and found that ΔGA/ was positively correlated with diabetes duration and negatively related to beta-cell function. In multivariable linear regression analyses, ΔGA/ was independently associated with diabetes duration. In conclusion, this study demonstrated that serum GA levels increase relative to levels with time.