Research Article

Design and Synthesis of a Novel Cationic Peptide with Potent and Broad-Spectrum Antimicrobial Activity

Table 5

Antimicrobial activities (MIC) of peptide against bacteria and fungi.

StrainMIC (µg/mL)
KW-13RFFR-15RFPP-18KWKK-13KPV-13KPV-8

Staphylococcus aureus1664>512>512>512>512
Staphylococcus epidermidis4128512>51232>512
Escherichia coli64256128256512>512
Klebsiella aeruginosa128>512>512>512>512>512
Pseudomonas aeruginosa128>512256>512>512>512
Monilia albicansNDNDNDNDNDND
Aspergillus niger256>512>512>512>512>512

MIC: minimal inhibitory concentration. These concentrations represent mean values of three independent experiments performed in duplicate. ND denotes no inhibition was observed even at a peptide concentration of 512 g/mL.