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BioMed Research International
Volume 2015 (2015), Article ID 580652, 12 pages
http://dx.doi.org/10.1155/2015/580652
Review Article

Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer

1Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, China
2The Department of Hematology and Oncology, The Second Hospital of Jilin University, Changchun 130041, China
3Department of Oral Surgery, Shengjing Hospital of Youyi Medical University, Jiulong 999077, Hong Kong
4Experimental Technology Center of Youyi Medical University, Jiulong 999077, Hong Kong
5Department of Statistics, School of Public Health, Youyi Medical University, Jiulong 999077, Hong Kong

Received 19 December 2014; Revised 1 March 2015; Accepted 2 March 2015

Academic Editor: Paul W. Doetsch

Copyright © 2015 Dong Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer. Methods. Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer. After selection of relevant studies, following strict inclusion and exclusion criteria, data was performed using STATA 12.0 software. Results. We retrieved 83 studies from database search using specific search terms. After multiple rounds of selection and elimination, 7 studies were finally identified as suitable to be included in our present meta-analysis, based on their relevance and data integrity. These 7 studies contained a combined total of 2,296 oral cancer patients and 3,647 healthy controls. Our findings demonstrated that +837 T > C (rs5275) polymorphism in COX-2 showed statistically significant differences in gene frequencies in case and control groups in allele model and dominant model. Similar results were obtained with COX-2 gene polymorphism 765 G > C (rs20417). On the other hand, 1195 A > G (rs689466) polymorphism in COX-2 did not confer susceptibility to oral cancers. Conclusion. Based on our results, COX-2 gene polymorphisms, +837 T > C (rs5275) and −765G > C (rs20417), showed clear links with oral cancer susceptibility, and the 1195A > G (rs689466) polymorphism did not show such a correlation.