Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer

Table 2

Comparisons of genotype and allele frequencies between the case and the control groups for the relationship between functional COX-2 gene polymorphisms and susceptibility to oral cancer.

SNP gene model	+837 T > C (rs5275)			−765 G > C (rs20417)			1195 G > A (rs689466)
	RR	95% CI		RR	95% CI	P	RR	95% CI	P
M allele versus W allele (allele model)	0.87	0.77–0.98	0.021	0.66	0.58–0.76	<0.001	0.94	0.87–1.02	0.164
WM + MM versus WW (dominant model)	0.53	0.40–0.72	<0.001	0.72	0.64–0.82	<0.001	0.95	0.89–1.02	0.186
MM versus WW (homozygous model)	0.68	0.47–0.99	0.042	0.26	0.16–0.43	<0.001	0.85	0.71–1.01	0.069
MM versus WM (heterozygous model)	1.01	0.92–1.11	0.806	1.11	1.03–1.18	0.004	1.01	0.93–1.10	0.734
MM versus WW + WM (recessive model)	0.72	0.49–1.06	0.093	0.32	0.19–0.54	<0.001	0.91	0.73–1.12	0.363

RR: relative risk; 95% CI: 95% confidential intervals.