Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer

Table 3

Meta-regression analyses on SNP, detecting method, year, country, ethnicity and sample size for exploring potential source of heterogeneity between functional COX-2 gene polymorphisms and susceptibility to oral cancer.

Heterogeneity factors	Coefficient	SE		P; (adjusted)	95% CI
					LL	UL
SNP	−0.071	0.082	−0.86	0.805	−0.299	0.158
Detecting method	1.964	0.812	2.42	0.181	−0.291	4.22
Year	0.301	0.130	2.32	0.206	−0.059	0.661
Country	0.124	0.098	1.27	0.588	−0.148	0.395
Ethnicity	−2.103	0.962	−2.19	0.232	−4.774	0.568
Sample size	0.002	0.001	2.21	0.230	−0.001	0.004

Note. SE: standard error; LL: lower limit; UL: upper limit; SNP: single-nucleotide polymorphism.