Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 581626, 2 pages
http://dx.doi.org/10.1155/2015/581626
Editorial

Membrane Transport: Ionic Environments, Signal Transduction, and Development of Therapeutic Targets

1Tokyo Medical University, Tokyo 160-0022, Japan
2Departments of Molecular Cell Physiology and Bio-Ionomics, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
3Japan Institute for Food Education and Health, St. Agnes’ University, Kyoto 602-8013, Japan
4Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
5Department of Physiology, Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia

Received 24 December 2014; Accepted 24 December 2014

Copyright © 2015 Akio Tomoda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. M. Canessa, J.-D. Horisberger, and B. C. Rossier, “Epithelial sodium channel related to proteins involved in neurodegeneration,” Nature, vol. 361, no. 6411, pp. 467–470, 1993. View at Publisher · View at Google Scholar · View at Scopus
  2. C. M. Canessa, L. Schild, G. Buell et al., “Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits,” Nature, vol. 367, no. 6462, pp. 463–467, 1994. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Asher, H. Wald, B. C. Rossier, and H. Garty, “Aldosterone-induced increase in the abundance of Na+ channel subunits,” The American Journal of Physiology—Cell Physiology, vol. 271, no. 2, part 1, pp. C605–C611, 1996. View at Google Scholar
  4. Y. Marunaka, “Characteristics and pharmacological regulation of epithelial Na+ channel (ENaC) and epithelial Na+ transport,” Journal of Pharmacological Sciences, vol. 126, no. 1, pp. 21–36, 2014. View at Publisher · View at Google Scholar
  5. D. G. Warnock, “Liddle syndrome: genetics and mechanisms of Na+ channel defects,” The American Journal of the Medical Sciences, vol. 322, no. 6, pp. 302–307, 2001. View at Google Scholar
  6. D. C. Eaton, M. N. Helms, M. Koval, F. B. Hui, and L. Jain, “The contribution of epithelial sodium channels to alveolar function in health and disease,” Annual Review of Physiology, vol. 71, pp. 403–423, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Dinudom, A. B. Fotia, R. J. Lefkowitz, J. A. Young, S. Kumar, and D. I. Cook, “The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 32, pp. 11886–11890, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. L. A. Chambers, B. M. Rollins, and R. Tarran, “Liquid movement across the surface epithelium of large airways,” Respiratory Physiology & Neurobiology, vol. 159, no. 3, pp. 256–270, 2007. View at Google Scholar
  9. S. M. Wilson, R. E. Olver, and D. V. Walters, “Developmental regulation of lumenal lung fluid and electrolyte transport,” Respiratory Physiology & Neurobiology, vol. 159, no. 3, pp. 247–255, 2007. View at Google Scholar
  10. Y. Marunaka, “Importance of expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells,” Respiratory Physiology & Neurobiology, vol. 196, pp. 39–42, 2014. View at Publisher · View at Google Scholar
  11. K. Nakajima, H. Miyazaki, N. Niisato, and Y. Marunaka, “Essential role of NKCC1 in NGF-induced neurite outgrowth,” Biochemical and Biophysical Research Communications, vol. 359, no. 3, pp. 604–610, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Peretti, M. Angelini, N. Savalli, T. Florio, S. H. Yuspa, and M. Mazzanti, “Chloride channels in cancer: focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets,” Biochimica et Biophysica Acta, 2014. View at Publisher · View at Google Scholar
  13. S. K. Parks, J. Chiche, and J. Pouyssegur, “Disrupting proton dynamics and energy metabolism for cancer therapy,” Nature Reviews Cancer, vol. 13, no. 9, pp. 611–623, 2013. View at Google Scholar
  14. E. P. Spugnini, P. Sonveaux, C. Stock et al., “Proton channels and exchangers in cancer,” Biochimica et Biophysica Acta, 2014. View at Publisher · View at Google Scholar
  15. R. Madonna and R. de Caterina, “Aquaporin-1 and sodium-hydrogen exchangers as pharmacological targets in diabetic atherosclerosis,” Current Drug Targets. In press.
  16. H. Miyazaki, A. Shiozaki, N. Niisato, and Y. Marunaka, “Physiological significance of hypotonicity-induced regulatory volume decrease: reduction in intracellular Cl- concentration acting as an intracellular signaling,” The American Journal of Physiology—Renal Physiology, vol. 292, no. 5, pp. F1411–F1417, 2007. View at Publisher · View at Google Scholar · View at Scopus