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BioMed Research International
Volume 2015, Article ID 583931, 8 pages
Research Article

Precuneus and Cingulate Cortex Atrophy and Hypometabolism in Patients with Alzheimer’s Disease and Mild Cognitive Impairment: MRI and 18F-FDG PET Quantitative Analysis Using FreeSurfer

1Service de Médecine Nucléaire, CHRU de Tours, boulevard Tonnellé, 37000 Tours, France
2Service de Médecine Nucléaire, CHR Orléans, avenue de l’Hôpital, 45000 Orléans, France
3INSERM U930, Université François Rabelais, boulevard Tonnellé, 37000 Tours, France
4Consultation Mémoire, CHRU de Tours, boulevard Tonnellé, 37000 Tours, France
5Service de Neuroradiologie, CHRU de Tours, boulevard Tonnellé, 37000 Tours, France
6INSERM CIC 1415, boulevard Tonnellé, 37000 Tours, France
7CEA/DSV/I2BM/CI-NAPS UMR6232, 14000 Caen, France
8INSERM U825, Université Paul Sabatier, 31400 Toulouse, France

Received 21 December 2014; Accepted 24 May 2015

Academic Editor: Adriana Alexandre Tavares

Copyright © 2015 Matthieu Bailly et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. The objective of this study was to compare glucose metabolism and atrophy, in the precuneus and cingulate cortex, in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI), using FreeSurfer. Methods. 47 individuals (17 patients with AD, 17 patients with amnestic MCI, and 13 healthy controls (HC)) were included. MRI and PET images using 18F-FDG (mean injected dose of 185 MBq) were acquired and analyzed using FreeSurfer to define regions of interest in the hippocampus, amygdala, precuneus, and anterior and posterior cingulate cortex. Regional volumes were generated. PET images were registered to the T1-weighted MRI images and regional uptake normalized by cerebellum uptake (SUVr) was measured. Results. Mean posterior cingulate volume was reduced in MCI and AD. SUVr were different between the three groups: mean precuneus SUVr was 1.02 for AD, 1.09 for MCI, and 1.26 for controls (); mean posterior cingulate SUVr was 0.96, 1.06, and 1.22 for AD, MCI, and controls, respectively (). Conclusion. We found graduated hypometabolism in the posterior cingulate cortex and the precuneus in prodromal AD (MCI) and AD, whereas atrophy was not significant. This suggests that the use of 18F-FDG in these two regions could be a neurodegenerative biomarker.