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BioMed Research International
Volume 2015, Article ID 584234, 10 pages
Research Article

Modeling the Effects of Multiple Intervention Strategies on Controlling Foot-and-Mouth Disease

Department of Mathematics, University of Zimbabwe, P.O. Box MP 167, Harare, Zimbabwe

Received 26 March 2015; Revised 4 September 2015; Accepted 13 September 2015

Academic Editor: Klaus Wimmers

Copyright © 2015 Steady Mushayabasa and Gift Tapedzesa. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Foot-and-mouth disease (FMD) is a threat to economic security and infrastructure as well as animal health, in both developed and developing countries. We propose and analyze an optimal control problem where the control system is a mathematical model for FMD that incorporates vaccination and culling of infectious animals. The control functions represent the fraction of animals that are vaccinated during an outbreak, infectious symptomatic animals that are detected and culled, and infectious nonsymptomatic animals that are detected and culled. Our aim was to study how these control measures should be implemented for a certain time period, in order to reduce or eliminate FMD in the community, while minimizing the interventions implementation costs. A cost-effectiveness analysis is carried out, to compare the application of each one of the control measures, separately or in combination.