Environmental Epigenetics: Crossroad between Public Health, Lifestyle, and Cancer Prevention

Table 4

Effect of histone modifications on transcription in mammals.

Modification	Histone	Site	Effect
Acetylation	H2A	Lys5	Activation
	H2B	Lys5	Activation
		Lys12	Activation
		Lys15	Activation
		Lys20	Activation
	H3	Lys4	Activation
		Lys9	Activation
		Lys14	Activation
		Lys18	Activation
		Lys23	Activation
		Lys27	Activation
	H4	Lys5	Activation
		Lys8	Activation
		Lys12	Activation
		Lys16	Activation
Methylation	H1	Lys26	Repression
	H3	Lys4	Activation
		Arg8	Repression
		Lys9	Repression
		Arg17	Activation
		Lys27	Repression
		Lys36	Activation
		Lys79	Activation
	H4	Lys20	Repression
		Lys59	Repression
Phosphorylation	H1	Ser27	Activation
	H2A	Ser1	Repression
	H3	Ser10	Activation
		Ser28	Activation
Ubiquitylation	H2B	Lys120	Activation