Table 4: Effect of histone modifications on transcription in mammals.

ModificationHistoneSiteEffect

AcetylationH2ALys5Activation
H2BLys5Activation
Lys12Activation
Lys15Activation
Lys20Activation
H3Lys4Activation
Lys9Activation
Lys14Activation
Lys18Activation
Lys23Activation
Lys27Activation
H4Lys5Activation
Lys8Activation
Lys12Activation
Lys16Activation

MethylationH1Lys26Repression
H3Lys4Activation
Arg8Repression
Lys9Repression
Arg17Activation
Lys27Repression
Lys36Activation
Lys79Activation
H4Lys20Repression
Lys59Repression

PhosphorylationH1Ser27Activation
H2ASer1Repression
H3Ser10Activation
Ser28Activation

UbiquitylationH2BLys120Activation