Research Article
Blood or Urine IP-10 Cannot Discriminate between Active Tuberculosis and Respiratory Diseases Different from Tuberculosis in Children
Table 1
Demographic and clinical characteristics of the subjects enrolled excluding those lost to follow-up.
| | | HIV-uninfected children | HIV-infected children | Healthy adult donors | | | Culture-confirmed | Highly probable | Probable | Total active TB | Respiratory diseases | Culture-confirmed | Highly probable | Probable | Total active TB | Respiratory diseases |
| | (%) | 7 | 7 | 5 | 19 | 61 | 0 | 10 | 3 | 13 | 18 | 33 |
| | Median age (IQR) | 12 (9–15) | 8 (1–14) | 3 (1–8) | 8 (2–14) | 4 (2–8) | — | 8 (1–14) | 14 | 9 (4–14) | 5 (3–8) | 26 (23–30) |
| | Male gender (%) | 3 (42.8) | 4 (57.1) | 2 (40.0) | 9 (47.4) | 34 (56.7) | — | | | 4 (30.8) | 8 (44.4) | 12 (46.2) |
| | TB localization | | | | | | | | | | | | | Pulmonary (PTB) | 7 (100) | 6 (85.7) | 5 (100) | 18 (94.7) | — | 0 (0) | 10 (100) | 3 (100) | 13 (100) | — | — | | Extrapulmonary (ETB) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | — | 0 (0) | 0 (0) | 0 (0) | 0 (0) | — | — | | PTB and EPT | 0 (0) | 1 (14.3) | 0 (0) | 1 (5.3) | — | 0 (0) | 0 (0) | 0 (0) | 0 (0) | — | — |
| | Diseases other than TB | | | | | | | | | | | | | Pneumonia | — | — | — | — | 24 (39.3) | — | — | — | — | 8 (44.5) | | | Respiratory tract infections | — | — | — | — | 20 (32.8) | — | — | — | — | 4 (22.2) | | | Miscellanea | — | — | — | — | 17 (27.9) | — | — | — | — | 6 (33.3) | |
| CD4+T-cell/mm3
Median (IQR) | — | — | — | — | — | — | 388 (328–536) | 184
(NA) | 386 (243–580) | 583 (480–831) | — |
| Urinary parameters
Median (IQR) | | | | | | | | | | | | | Creatinuria | 43.4 (27.0–65.1) | 41.1 (26.6–81.6) | 18.6 (11.2–36.7) | 38.3 (18.6–65.1) | 28.7 (12.5–49.6) | — | 30.5 (9.4–72.9) | 59.8
(NA) | 37.7 (13.3–69.6) | 37.8 (6.9–48.9) | 105.0 (81.4–137.2) | | Specific gravity | 1.01 (1.01–1.02) | 1.02 (1.01–1.02) | 1.02 (1.01–1.03) | 1.02 (1.01–1.02) | 1.01 (1.01–1.02) | — | 1.01 (1.01–1.02) | 1.02
(NA) | 1.01 (1.01–1.02) | 1.02 (1.02–1.03) | 1.02 (1.02–1.03) | | pH | 6.0 (6.0–6.5) | 6.3
(6.0–7.3) | 6.0
(6.0–7.0) | 6
(6.0–6.6) | 6.5 (6.0–8.0) | — | 6.0 (6.0–6.6) | 6.0
(NA) | 6.0 (6.0–6.8) | 6.0 (6.0–6.6) | 7.0
(6.0–8.0) |
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TB: tuberculosis; IQR: interquartile range; HIV: Human Immunodeficiency Virus; QFT-IT: QuantiFERON TB-Gold In-Tube; TST: tuberculin skin test.
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