Research Article
Blood or Urine IP-10 Cannot Discriminate between Active Tuberculosis and Respiratory Diseases Different from Tuberculosis in Children
Table 3
QFT and TST results of patients excluding those lost to follow-up.
| | | HIV-uninfected children | HIV-infected children | Healthy adult donors | | | Active TB categories | Total active TB |
Respiratory diseases | p value | Active TB categories | Total active TB |
Respiratory diseases | p value | | | Culture-confirmed | Highly probable | Probable | Culture-confirmed | Highly probable | Probable |
| | 7 | 7 | 5 | 19 | 60 | | 0 | 10 | 3 | 13 | 18 | | 33 |
| | QFT-IT (%) | | | | | | 0.001 | | | | | | 0.11 | | | Performed | 5 (71.4) | 7 (100.0) | 5 (100.0) | 17 (89.5) | 59 (98.3) | | — | 9 (90.0) | 3 (100.0) | 12 (92.3) | 17 (94.4) | | 32 (97.0) | | Positive | 3 (60.0) | 4 (57.1) | 2 (40.0) | 9 (47.4) | 6 (10.2) | | — | 1 (11.1) | 1 (33.3) | 2 (16.7) | 0 (0) | | 13 (40.6) | | Negative | 2 (40.0) | 2 (28.6) | 3 (60.0) | 7 (36.8) | 50 (84.7) | | — | 8 (88.9) | 2 (66.7) | 10 (83.3) | 14 (82.4) | | 19 (59.4) | | Indeterminate | — | 1 (14.3) | — | 1 (5.3) | 3 (5.1) | | — | — | — | — | 3 (17.6) | | — | | Not performed | 2 (28.6) | — | — | 2 (10.5) | 1 (1.7) | | — | 1 (10.0) | — | 1 (7.7) | 1 (5.6) | | 1 (3.0) |
| | TST test (%) | | | | | | <0.0001 | | | | | | 0.15 | | | Performed | 6 (85.7) | 7 (100.0) | 5 (100.0) | 18 (94.7) | 60 (100.0) | | — | 10 (100.0) | 3 (100.0) | 13 (100.0) | 18 (100) | | 0 | | Positive | 3 (50.0) | 6 (85.7) | 2 (40.0) | 11 (57.9) | 10 (16.7) | | — | 1 (10.0) | 2 (66.7) | 3 (23.1) | 1 (5.6) | | — | | Negative | 3 (50.0) | 1 (14.3) | 3 (60.0) | 7 (36.8) | 50 (83.3) | | — | 9 (90.0) | 1 (33.3) | 10 (76.9) | 17 (94.4) | | — | | Not performed | 1 (14.3) | — | — | 1 (5.3) | — | | — | — | — | — | 0 (0) | | 33 (100.0) |
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TB: tuberculosis; IQR: interquartile range; HIV: Human Immunodeficiency Virus; QFT-IT: QuantiFERON TB-Gold In-Tube; TST: tuberculin skin test.
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