Table 1: Design of the in vivo study. For each animal the end point as well as number and type of implants is specified. Total number of implants per formulation was 48, with 16 samples per end point. Six–ten samples were used for flow cytometry and the rest for histology.

AnimalEnd point (weeks)Number of OP implantsNumber of OP + LA implantsNumber of OP + CO implants

11422
24224
312242
41422
512224
64242
712422
812224
91242
104422
114224
121242
134422
141224
154242
1612422
171224
1812242

Total number484848