Vitamin D Can Ameliorate Chlorhexidine Gluconate-Induced Peritoneal Fibrosis and Functional Deterioration through the Inhibition of Epithelial-to-Mesenchymal Transition of Mesothelial Cells

Figure 6

Vitamin D3 inhibited transforming growth factor-β1- (TGF-β1-) induced migration activity of mesothelial cells (MCs) in vitro. (a) Representative images of MCs in the wound-healing assay. MCs were treated with TGF-β1 (1 ng/mL) with or without 1α,25(OH)₂D₃ (vit. D, 10⁻⁶ mol/L). (b) Quantitative analysis of the width of the postscratch cell-free space at each follow-up time point. (c) The difference in the migration distance at 6 hr (Δ6 hr) is represented in (c). TGF-β1 promoted MCs migration activity was inhibited by vitamin D3. () Graphical data represent mean ± S.D. ().

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