Vitamin D Can Ameliorate Chlorhexidine Gluconate-Induced Peritoneal Fibrosis and Functional Deterioration through the Inhibition of Epithelial-to-Mesenchymal Transition of Mesothelial Cells
Vitamin D3 inhibited transforming growth factor-β1- (TGF-β1-) induced migration activity of mesothelial cells (MCs) in vitro. (a) Representative images of MCs in the wound-healing assay. MCs were treated with TGF-β1 (1 ng/mL) with or without 1α,25(OH)2D3 (vit. D, 10−6 mol/L). (b) Quantitative analysis of the width of the postscratch cell-free space at each follow-up time point. (c) The difference in the migration distance at 6 hr (Δ6 hr) is represented in (c). TGF-β1 promoted MCs migration activity was inhibited by vitamin D3. () Graphical data represent mean ± S.D. ().