Research Article
Mammalian Cell Culture Process for Monoclonal Antibody Production: Nonlinear Modelling and Parameter Estimation
Table 1
Macroreactions of the mAb production process [
4,
27].
| Reaction number | Macroreaction scheme |
| 1 | GLC → 2LAC | 2 | GLC + 2GLU → 2ALA + 2LAC | 3 | GLC + 2GLU → 2ASP + 2LAC | 4 | GLU → PRO | 5 | ASN → ASP + NH3 | 6 | GLN + ASP → ASN + GLU | 7 | 0.0508GLC + 0.0577GLN + 0.0133ALA + 0.006ASN + 0.0201ASP + 0.0016GLU + 0.081PRO → BM | 8 | 0.0104GLN + 0.011ALA + 0.072ASN + 0.082ASP + 0.0107GLU + 0.0148PRO → MAb | 9 | GLN → GLU + NH3 |
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