TY - JOUR
A2 - Zubair, Swaleha
AU - Wang, Wan-Jhen
AU - Wu, Yu-Sheng
AU - Chen, Sherwin
AU - Liu, Chi-Feng
AU - Chen, Shiu-Nan
PY - 2015
DA - 2015/06/17
TI - Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma
SP - 604385
VL - 2015
AB - The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β production in serum. In addition, IL-12 and IFN-γ mRNA expression were significantly increased, but IL-6, IL-10, COX-2, and TGF-β mRNA expression were substantially following oral mushroom polysaccharides treatments. The study highlights the efficacious effect of mushroom polysaccharides for ameliorating the immune suppression in the tumor microenvironment. Increased M1 phenotype of tumor-associated macrophages and attenuated M2 phenotype of tumor-associated macrophages could be achieved by ingesting mushroom polysaccharides.
SN - 2314-6133
UR - https://doi.org/10.1155/2015/604385
DO - 10.1155/2015/604385
JF - BioMed Research International
PB - Hindawi Publishing Corporation
KW -
ER -