TY - JOUR A2 - Zubair, Swaleha AU - Wang, Wan-Jhen AU - Wu, Yu-Sheng AU - Chen, Sherwin AU - Liu, Chi-Feng AU - Chen, Shiu-Nan PY - 2015 DA - 2015/06/17 TI - Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma SP - 604385 VL - 2015 AB - The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β production in serum. In addition, IL-12 and IFN-γ mRNA expression were significantly increased, but IL-6, IL-10, COX-2, and TGF-β mRNA expression were substantially following oral mushroom polysaccharides treatments. The study highlights the efficacious effect of mushroom polysaccharides for ameliorating the immune suppression in the tumor microenvironment. Increased M1 phenotype of tumor-associated macrophages and attenuated M2 phenotype of tumor-associated macrophages could be achieved by ingesting mushroom polysaccharides. SN - 2314-6133 UR - https://doi.org/10.1155/2015/604385 DO - 10.1155/2015/604385 JF - BioMed Research International PB - Hindawi Publishing Corporation KW - ER -