Research Article
Modern Evaluation of Liquisolid Systems with Varying Amounts of Liquid Phase Prepared Using Two Different Methods
Table 1
Composition of liquisolid tablets.
| Sample | Rosuvastatin | PEG 400 | Neusilin US2 | Aerosil 200 | Kollidon CL-F | Mg stearate | Lactose | | mg | % | mg | % | mg | % | mg | % | mg | % | mg | % | mg | % |
| 40%w | 10 | 1.5 | 123 | 18.9 | 332.5 | 51.2 | 6.5 | 1.0 | 32.5 | 5.0 | 6.5 | 1.0 | 139.0 | 21.4 | 0.4 | 50%w | 10 | 1.5 | 123 | 18.9 | 266.0 | 40.9 | 5.3 | 0.8 | 32.5 | 5.0 | 6.5 | 1.0 | 206.7 | 31.8 | 0.5 | 60%w | 10 | 1.5 | 123 | 18.9 | 221.7 | 34.1 | 4.4 | 0.7 | 32.5 | 5.0 | 6.5 | 1.0 | 251.9 | 38.8 | 0.6 | 70%w | 10 | 1.5 | 123 | 18.9 | 190.0 | 29.2 | 3.8 | 0.6 | 32.5 | 5.0 | 6.5 | 1.0 | 284.2 | 43.7 | 0.7 | 80%w | 10 | 1.5 | 123 | 18.9 | 166.4 | 25.6 | 3.3 | 0.5 | 32.5 | 5.0 | 6.5 | 1.0 | 308.3 | 47.4 | 0.8 | 90%w | 10 | 1.5 | 123 | 18.9 | 147.8 | 22.7 | 3.0 | 0.5 | 32.5 | 5.0 | 6.5 | 1.0 | 327.2 | 50.3 | 0.9 | 100%w | 10 | 1.5 | 123 | 18.9 | 133.0 | 20.5 | 2.7 | 0.4 | 32.5 | 5.0 | 6.5 | 1.0 | 342.3 | 52.7 | 1.0 | 110%w | 10 | 1.5 | 123 | 18.9 | 121.0 | 18.6 | 2.4 | 0.4 | 32.5 | 5.0 | 6.5 | 1.0 | 354.6 | 54.6 | 1.1 | 120%w | 10 | 1.5 | 123 | 18.9 | 110.8 | 17.1 | 2.2 | 0.3 | 32.5 | 5.0 | 6.5 | 1.0 | 365.0 | 56.2 | 1.2 |
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means liquid load factor.
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