Modern Evaluation of Liquisolid Systems with Varying Amounts of Liquid Phase Prepared Using Two Different Methods

Table 4

Properties of liquisolid tablets prepared by simple blending and spraying.

Sample	Simple blending					Spraying
	Friability	Disintegration	Uniformity; of mass	Drug; content	Height	Friability	Disintegration	Uniformity; of mass	Drug; content	Height
	%	s	mg	%	mm	%	s	mg	%	mm
40%w	0.52	3.0 ± 0.0	650.23 ± 5.28	103.01 ± 5.08	8.20 ± 0.07	0.95	18.0 ± 0.0	650.12 ± 3.37	95.58 ± 5.00	6.06 ± 0.05
50%w	0.10	38.0 ± 3.0	649.76 ± 4.25	98.82 ± 7.95	6.48 ± 0.15	0.18	24.0 ± 5.0	657.07 ± 6.70	96.55 ± 1.70	6.22 ± 0.13
60%w	0.06	50.0 ± 3.0	654.43 ± 5.98	99.86 ± 6.66	5.59 ± 0.09	0.04	60.0 ± 13.0	650.50 ± 1.97	106.07 ± 0.77	4.96 ± 0.11
70%w	0.23	159.0 ± 3.0	651.31 ± 4.13	92.29 ± 3.11	4.90 ± 0.04	0.04	98.0 ± 17.0	656.66 ± 6.33	97.35 ± 0.80	4.66 ± 0.06
80%w	0.43	107.0 ± 5.0	655.13 ± 7.71	109.42 ± 4.67	4.73 ± 0.08	0.05	35.0 ± 0.0	656.82 ± 4.30	103.43 ± 4.29	5.05 ± 0.02
90%w	0.56	51.0 ± 0.0	664.31 ± 5.46	66.10 ± 3.83	4.88 ± 0.03	0.03	73.0 ± 0.0	654.74 ± 5.60	95.92 ± 1.89	4.81 ± 0.02
100%w	0.79	39.0 ± 0.0	649.44 ± 3.68	116.76 ± 5.03	4.87 ± 0.03	0.08	30.0 ± 0.0	655.75 ± 0.82	90.55 ± 1.95	4.47 ± 0.17
110%w	0.85	40.0 ± 4.0	659.11 ± 3.29	118.19 ± 13.15	4.94 ± 0.05	0.25	25.0 ± 0.0	652.93 ± 1.70	109.20 ± 1.14	4.61 ± 0.05
120%w	1.45	21.0 ± 0.0	653.12 ± 1.78	85.68 ± 23.70	4.82 ± 0.05	0.16	18.0 ± 0.0	658.05 ± 1.05	112.38 ± 0.92	4.30 ± 0.00