Temozolomide and Radiotherapy versus Radiotherapy Alone in High Grade Gliomas: A Very Long Term Comparative Study and Literature Review

Table 6

Univariate analysis groups A + B and group C patients.

Prognostic factors	Pts’ number	2-year OS
Age
≤55 years	47	29%	0.007
>55 years	81	15%
Sex
Male	74	17.5%	n.s.
Female	54	22%
Histology
Anaplastic astrocytoma	36	40%	<0.0001
Glioblastoma; multiforme	92	11.8%
Surgery
Stereotactic biopsy	23	25%	n.s.
Subtotal resection	65	14%
Total resection	40	26%
Treatment schedule
RT + TMZ	64	29.6%	0.0001
RT alone	64	9.3%
RT total dose
≥60 Gy	109	22%	0.003
<60 Gy	19	10.5%