Research Article
Amelioration of Isoproterenol-Induced Oxidative Damage in Rat Myocardium by Withania somnifera Leaf Extract
Table 3
WSLEt ameliorates the oxidative damage caused by ISO as demonstrated by the changes in LPO levels and the activities of SOD, GRx, GPx, and GST.
| Parameters | Group | Sham | WSLEt + Sham | WSLEt + ISO | ISO |
| LPO (nmol TBARS/mg of protein) | 42.77 ± 1.05a | 37.18 ± 1.85a | 40.02 ± 1.17a | 82.17 ± 1.35b | SOD (units/mg of protein) | 1.45 ± 0.02ab | 1.58 ± 0.16a | 0.33 ± 0.02b | 0.10 ± 0.00c | GRx (nmol NADPH oxidized/min/mg of protein) | 97.56 ± 2.09a | 90.57 ± 1.79a | 97.14 ± 6.05a | 75.59 ± 9.79b | GPx (nmol NADPH oxidized/min/mg of protein) | 2.15 ± 0.45a | 3.12 ± 0.16b | 1.98 ± 0.00ab | 0.96 ± 0.00c | GST (nmol of CDNB conjugated/min/mg of protein) | 2.04 ± 0.06a | 4.05 ± 0.19b | 1.99 ± 0.11a | 0.85 ± 0.02c |
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Results are expressed as mean values ± SD; . a,b,cValues in the same row that do not share superscript letters (a, b, c) differ significantly at .
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