Research Article

Amelioration of Isoproterenol-Induced Oxidative Damage in Rat Myocardium by Withania somnifera Leaf Extract

Table 3

WSLEt ameliorates the oxidative damage caused by ISO as demonstrated by the changes in LPO levels and the activities of SOD, GRx, GPx, and GST.

ParametersGroup
ShamWSLEt + ShamWSLEt + ISOISO

LPO (nmol TBARS/mg of protein)42.77 ± 1.05a37.18 ± 1.85a40.02 ± 1.17a82.17 ± 1.35b
SOD (units/mg of protein)1.45 ± 0.02ab1.58 ± 0.16a0.33 ± 0.02b0.10 ± 0.00c
GRx (nmol NADPH oxidized/min/mg of protein)97.56 ± 2.09a90.57 ± 1.79a97.14 ± 6.05a75.59 ± 9.79b
GPx (nmol NADPH oxidized/min/mg of protein)2.15 ± 0.45a3.12 ± 0.16b1.98 ± 0.00ab0.96 ± 0.00c
GST (nmol of CDNB conjugated/min/mg of protein)2.04 ± 0.06a4.05 ± 0.19b1.99 ± 0.11a0.85 ± 0.02c

Results are expressed as mean values ± SD; . a,b,cValues in the same row that do not share superscript letters (a, b, c) differ significantly at .