BioMed Research International / 2015 / Article / Tab 5

Research Article

Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis

Table 5

Analysis of differentially expressed orthologs genes with popular mechanisms of aging.

MechanismsGenes involved

Mitochondrion ALDH18A1, ALDOC, ARG2, BCL2L10, BID, CAPRIN2, CYP11A1 DSP, FAM136A, FEN1, GATM, ILF3, LACTB2 MTIF3, NADKD1, P4HA1, PPP3CB, RARS2, SHMT1, TOMM34, TPP1, and USP30

Oxidation reduction and electron transportALDH18A1, AOX1, CYP11A1, FADS1, HSD17B1, KDM1A, LDHAL6A, NARF, NELL1, P4HA1, and RETSAT

Apoptosis ALDOC, ARHGEF7, AVEN, BARD1, BCL2L10, BCLAF1, BID, BRCA1, BUB1B, CASP2, CDK1, CSE1L, DEDD, F2, GAL, HELLS, KRT8, MAEL, MMP9, MSH2, NELL1, NPM1, SOX4, TIA1, TUBB, and TUBB2C

Immune system AOX1, BCL11A, CCNB2, CHD7, CHIT1, CLEC1A, F2, GAL, GLMN, IGFBP4, IGHE, IL1R1, ILF2, JARID2, MASP1, MMP9, MSH2, OPRK1, PPP3CB, SOX4, TACC3, TCF3, THY1, TUBB, TUBB2C, and XRCC6

DNA replication and repair ASF1A, BARD1, BRCA1, CCNO, CHAF1A, CHEK1, DKC1, DTL, FANCE, FANCI, FEN1, GINS2, HMGA1, MCM10, MCM3, MCM5, MCM7, MORF4L1, MSH2, NASP, NEIL3, ORC6L, PAPD7, PARP1, POLD1, POLD3, PTTG1, RAD50, RAD51, RAD51C, RBM4, RFC3, RFC4, RMI2, RUVBL2, SFPQ, SSRP1, TDP1, TRIP13, TYMS, and XRCC6

Methylation DHX9, DNMT3A, DNMT3B, FBL, FUS, HELLS, HMGA1, HNRNPD, HNRNPK, HNRNPU, HNRPDL, ILF3, MAEL, PABPC4, PRMT5, PRMT7, RAP1A, RASL10A, RHOQ, RRAS2, SFPQ, SRSF1, SUV39H2, TDRD1, TGS1, THOC4, TUBA1B, and TUBB

Reproduction AMH, BCL2L10, CCNB1, CCNE1, CELSR2, CEP57, CHD7, CHEK1, DAZAP1, DEDD, DNMT3A, FIGLA, HIST1H1A, HSF2BP, LHX8, MAEL, MBD2, MSH2, NLRP14, NPM2, OOEP, PPAP2B, PRMT7, PTTG1, RAD51C, RPL39L, STRBP, TDRD1, TRIP13, ZP2, ZP3, and ZP4

Aging NPM1, ENG, MSH2, FADS1, and ALDOC

Telomere DKC1, PARP1, XRCC6, and RAD50

Orthologs genes upregulated in old monkey ovaries.