Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis

Table 6

Results of functional annotation of orthologs genes upregulated in old monkey ovary compared to young monkey ovary.

Category	Term	Genes
Regulation of cellular process	Negative regulation of catalytic activity/negative regulation of molecular function	PKIG, CAST, ENG, APOC1, and THY1
	Negative regulation of cellular component organization	RHOQ, APOC1, and THY1
	Negative regulation of nitrogen compound metabolic process/negative regulation of cellular biosynthetic process/negative regulation of biosynthetic process	PKIG, ENG, PBXIP1, APOC1, and CCDC85B
Aging	Aging	ENG, FADS1, and ALDOC
Defense response	Response to wounding	IGFBP4, AOX1, ENG, TFPI, and MASP1
	Defense response	CLEC1A, IGFBP4, AOX1, IL1R1, and MASP1
	Response to endogenous stimulus	CYP11A1, RHOQ, FADS1, and ALDOC
Oxidation reduction	Oxidation reduction/fat-soluble vitamin metabolic process/unsaturated fatty acid biosynthetic process	CYP11A1, AOX1, RETSAT, FADS1, and FADS2
Cell growth	Regulation of cell growth	IGFBP4,WISP2, and CCDC85B
KEGG_PATHWAY	Leukocyte transendothelial migration	MMP9, RAP1A, MYL9, and THY1
	Biosynthesis of unsaturated fatty acids	FADS1, FADS2

Functional categories of genes were assembled from annotation and PubMed.