Heterogeneity of Breast Cancer Associations with Common Genetic Variants in FGFR2 according to the Intrinsic Subtypes in Southern Han Chinese Women
Table 4
Frequencies of inferred haplotypes of FGFR2 (rs1078806, rs2420946, rs2981579, and rs2981582) in breast cancer cases and controls.
Haplotypea
Frequency
OR (95% CI)b
Total ()
Controls ()
Cases ()
T-C-C-C
0.443
0.467
0.408
1.00
—
C-T-T-T
0.229
0.216
0.247
1.30 (1.07–1.57)
8.1 × 10−3
T-T-T-C
0.066
0.059
0.076
1.44 (1.04–1.99)
2.8 × 10−2
T-C-T-C
0.059
0.054
0.065
1.42 (1.01–2.00)
4.5 × 10−2
T-C-C-T
0.057
0.052
0.064
1.38 (0.99–1.93)
5.9 × 10−2
C-T-T-C
0.046
0.047
0.045
1.14 (0.78–1.66)
5.0 × 10−1
T-T-T-T
0.045
0.043
0.047
1.25 (0.84–1.85)
2.8 × 10−1
T-T-C-T
0.019
0.021
0.015
0.89 (0.48–1.65)
7.1 × 10−1
C-C-T-C
0.014
0.018
0.009
0.63 (0.29–1.35)
2.4 × 10−1
Rare <1%
0.024
0.023
0.023
1.11 (0.64–1.95)
7.0 × 10−1
Haplotype in the order of FGFR2 SNPs rs1078806, rs2420946, rs2981579, and rs2981582. bAdjusted for age, age at first full-term pregnancy, menopausal status, and hormonal therapy status. Abbreviations: OR, odds ratio; CI, confidence interval.
