MicroRNA and mRNA Features of Malignant Pleural Mesothelioma and Benign Asbestos-Related Pleural Effusion

Table 4

Integrated analysis of mRNA and microRNAs.

	In population	In study set	Estimate	mRNA	miRNA	Both
KEGG_AXON_GUIDANCE	129	38	0.94	12	28	2
PID_NOTCH_PATHWAY	59	23	0.61	6	17	0
REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX	63	23	0.56	10	14	1
KEGG_ADHERENS_JUNCTION	75	28	0.54	15	14	1
PID_AVB3_INTEGRIN_PATHWAY	75	34	0.47	8	27	1
REACTOME_SIGNALING_BY_NOTCH	103	30	0.42	16	18	4
PID_E2F_PATHWAY	74	24	0.41	11	16	3
KEGG_PATHWAYS_IN_CANCER	328	88	0.40	45	49	6

Number of overexpressed mRNAs in the pathway.
Number of gene targets of underexpressed microRNAs in the pathway.
Number of common genes in * and **.
In Study Set: number of genes in the pathway from genes selected for the analysis.
In Population: number of genes in the pathway.
The column “estimate” for MGSA indicates the marginal value of a term being in the “active” state; 0.4 was used as the threshold.