BioMed Research International / 2015 / Article / Tab 1

Review Article

Zebrafish as a Model for the Study of Human Myeloid Malignancies

Table 1

Zebrafish animal models of myeloid malignancies.

Gene namePromoter and expression constructTypeRefs



kRASG12D B-actin-LoxP-EGFP-LoxP-kRASG12D; hsp70-CreMPD[61]

NUP98-HOXA9 spi-1-loxP-EGFP-loxP-NUP98-HOXA9; hsp70-CreMPN[62]

Stat5.1 mutantsConstitutively active mutants of Stat5.1Tumor-like lesions; increased numbers of early and late myeloid cells, erythrocytes, and B cells[65]

NPM1 mutantpCS2cmv-NPM1c-EGFPNo AML; increased numbers of definitive hematopoietic cells[66]

tel-jak2a pCS2cmv-Flag-tel-jak2a; spi-1-Flag-tel-jak2aNo AML; anemic; perturbed intermediate cell mass; accumulation of large cells near the heart[67]

AML1 pCS2cmv-runx1No AML; enlarged heart and ectopic blood[24]

AML1-ETO pCS2cmv-RUNX1-CBF2T1No AML; defective development of blood and circulation and internal hemorrhaging[24]

AML1-ETO hsp-AML1-ETONo AML; loss of gata1 hematopoietic cells in the posterior blood islands[68]

AML1-ETO + Gro3 MOhsp-AML1-ETONo apparent AML; enhanced the accumulation of blast cells[68]

FLT3-ITD CMV-FLT3-ITD-T2a-EGFPEctopic myeloid cell expansion
CMV-FLT3-TKD-T2a-EGFPEctopic myeloid cell expansion resistant to AC220[69]
CMV-FLT3-ITD-TKD-T2a-EGFPConferred resistance to AC220 treatment

AML: acute myeloid leukemia; MPD: myeloproliferative disorder; MPN: myeloproliferative neoplasm; MO: morpholino.

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