BioMed Research International / 2015 / Article / Tab 2

Review Article

Can Acute Pain Treatment Reduce Postsurgical Comorbidity after Breast Cancer Surgery? A Literature Review

Table 2

Analgesic effect on the persistent postsurgical pain.

Surgical procedureAnalgesic modalityOutcomesStudy designSample size Journals (year)1st authorCitation

Nerve block
Pt mastectomy with or without ALND, mastectomy with or without ALNDPVB with 0.5% bupivacaine versus saline before surgeryIntensity and prevalence of pain reduced 12 mo after the surgeryProspective studyAnesth. Analg. (2006)Kairaluoma [33]
Pt mastectomy with ALND, mastectomy with or without ALND or SLNBPVB with 0.5% ropivacaine before surgery versus wound injection with 0.5% ropivacaine at the end of surgeryPrevalence of pain 12 mo after the surgery was similarly low in both groupsProspective studyAnn. Surg. Oncol. (2014)Chiu [34]
Mastectomy with or without ALNDPVB with 0.4% ropivacaine versus saline daily for 3 days after the surgeryPrevalence of pain 12 mo after the surgery was lower in PVB groupProspective studyAnn. Surg. Oncol. (2014)Ilfeld [35]

LA injection at surgical site
Mastectomy with ALND,
Pt mastectomy with ALND
EMLA versus placebo for 4 days after the surgeryPain at the surgical site reduced 3 mo after the surgeryProspective studyReg. Anesth. Pain Med. (2000)Fassoulaki [30]
Mastectomy with ALND,
Pt mastectomy with ALND
Ropivacaine 0.75% versus saline at the end of surgerySimilar pain condition 2 mo after the surgeryProspective studyBMC Anesthesiol. (2011)Vigneau [28]
Pt mastectomy with ALND,
mastectomy with or without ALND or SLNB
Ropivacaine 0.375% versus saline at the end of surgerySimilar pain condition 3–12 mo after the surgeryProspective studyAnesthesiology (2013)Albi-Feldzer [29]
Mastectomy with reconstructionLevobupivacaine 0.25% for 2 days after the surgeryLevobupivacaine reduced pain intensity 3 mo after the surgeryProspective studyWorld J. Surg. Oncol. (2014)Strazisar [31]

Systemic analgesic drug
Mastectomy with ALND,
Pt mastectomy with ALND
Mexiletine versus gabapentin versus placebo for 10 daysIntensity and incidence of pain 3 months after the surgery were similar. Sensation of burning pain reduced in mexiletine and gabapentin groupProspective studyAnesth. Analg. (2002)Fassoulaki [38]
Mastectomy with ALND,
Pt mastectomy with ALND
Venlafaxine versus gabapentin versus placebo for 10 days after the surgeryVenlafaxine reduced the incidence of pain 6 mo after the surgeryProspective studyClin. J. Pain (2010)Amr [37]
Pt Mastectomy with ALND or SLNB, mastectomy with ALND or SLNBIV lidocaine versus saline during the surgeryPrevalence of pain 3 mo after the surgery reduced in lidocaine groupProspective studyClin. J. Pain (2012)Grigoras [36]

Pt mastectomy: partial mastectomy, SLNB: sentinel lymph node biopsy, and ALND: axillary lymph node dissection.