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BioMed Research International
Volume 2015 (2015), Article ID 643878, 9 pages
Research Article

Acute Effects of the Novel Psychoactive Drug 2C-B on Emotions

1Department of Pharmacology and Department of Psychiatry, Universitat Autònoma de Barcelona, Doctor Aiguader 80, 08003 Barcelona, Spain
2Hospital del Mar Medical Research Institute (IMIM), Doctor Aiguader 88, 08003 Barcelona, Spain
3Institute of Neuropsychiatry and Addictions (INAD), Parc de Salut Mar, Paseo Marítimo 25, 08003 Barcelona, Spain
4Hospital Universitari Germans Trias i Pujol-HUGTP-IGTP, Carretera de Canyet, s/n, 08916 Badalona, Spain

Received 7 August 2015; Accepted 27 September 2015

Academic Editor: Giovanni Martinotti

Copyright © 2015 Débora González et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. 2C-B (Nexus) is one of the most widespread novel psychoactive substances. There is limited information about its pharmacological properties, and few studies in humans concern its acute and chronic effects. 2C-B has been classified as a stimulant, hallucinogen, entactogen, and/or empathogen. Objectives. To evaluate the emotional, subjective, and cardiovascular effects of 2C-B. Methods. Twenty healthy recreational 2C-B users (12 women) self-administered a 20 mg dose of 2C-B. Evaluations included emotional (IAPS, FERT, and speech), subjective (visual analog scales, ARCI, VESSPA, HRS, and POMS questionnaires), and cardiovascular effects (blood pressure and heart rate). Results. Positive subjective effects predominated with a reduction of anger under the influence of 2C-B. It did, however, increase reactivity to negative emotional stimuli and decrease the ability to recognize expressions of happiness. Augmented emotionality in speech could be appreciated by others. 2C-B induced euphoria and well-being, changes in perceptions, and slight hallucinogenic states. Mild sympathetic actions were observed. Conclusions. The specific profile that 2C-B exerts on emotions suggests its classification as an entactogen with psychedelic properties.