Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015 (2015), Article ID 646853, 8 pages
Research Article

Expression of MMP-9 and VEGF in Meningiomas and Their Correlation with Peritumoral Brain Edema

1Department of Medical Pathomorphology, Medical University of Bialystok, Ulica Waszyngtona 13, 15-269 Bialystok, Poland
2Department of Neurosurgery, Medical University of Bialystok, Ulica Marii Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland

Received 22 August 2014; Revised 4 February 2015; Accepted 13 February 2015

Academic Editor: Gang Liu

Copyright © 2015 Joanna Reszec et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Meningiomas constitute up to 13% of all intracranial tumors. The predictive factors for meningioma have not been unambiguously defined; however some limited data suggest that the expression of matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) may be associated with the presence of peritumoral brain edema (PTBE) and worse clinical outcome. The aim of this study was to analyze the expressions of MMP-9 and VEGF in a group of meningiomas of various grades and to study associations between these two markers and PTBE. The study included patients with supratentorial meningiomas. The patients were divided into low- (G1) and high-grade meningiomas (G2 and G3). PTBE was assessed on MRI. The expressions of VEGF and MMP-9 were determined immunohistochemically. The expression of MMP-9 was observed significantly more often in G3 meningiomas than in lower grade tumors. The presence of stage II or III PTBE was associated with a significant increase in MMP-9 expression. The expression of VEGF did not differ across the PTBE stages. Our findings point to a significant role of MMP-9 and VEGF in the pathogenesis of peritumoral brain edema in low- and high-grade meningiomas.