Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort

Figure 2

Manhattan plot of the observed values from the GWAS of cingulate cortical Aβ load. More than 580,000 SNPs were tested for association with cingulate cortical Aβ burden under an additive model, with age, gender, and diagnosis as covariates. Genome-wide significant associations (exceeding the threshold represented by the red line and determined by Bonferroni correction) were identified on chromosome 19 within the APOE and its neighboring regions.