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BioMed Research International
Volume 2015 (2015), Article ID 650282, 10 pages
http://dx.doi.org/10.1155/2015/650282
Research Article

The Effect of Risk Factors on the Levels of Chemical Elements in the Tibial Plateau of Patients with Osteoarthritis following Knee Surgery

1Department of Biology and Medical Parasitology, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland
2Department of Chemical Hazards and Genetic Toxicology, Institute of Occupational Medicine and Environmental Health, Koscielna 13, 71-200 Sosnowiec, Poland
3Chair and Clinic of Orthopaedics and Traumatology, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland
4Department of Ecology, Environmental Management and Protection, Slowackiego 17, 71-434 Szczecin, Poland
5Department of Animal Reproduction Biotechnology and Environmental Hygiene, West Pomeranian University of Technology, Doktora Judyma 6, 71-466 Szczecin, Poland
6Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland
7Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24, 71-460 Szczecin, Poland

Received 20 March 2015; Revised 13 May 2015; Accepted 18 May 2015

Academic Editor: Kengo Yamamoto

Copyright © 2015 Natalia Lanocha-Arendarczyk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to evaluate the aforementioned chemical elements in tibial plateau samples obtained during knee arthroplasty. The gender-specific analysis of chemical element levels in the bone samples revealed that there were statistically significant differences in the concentration of Pb and Se/Pb ratio. The contents of elements in the tibial plateau in the patients with osteoarthritis (OA) can be arranged in the following descending order: F > K > Zn > Fe > Sr > Pb > Mn > Se > Cd > THg. We observed statistical significant effects of environmental factors including smoking, seafood diet, and geographical distribution on the levels of the elements in tibial bone. Significant positive correlation coefficients were found for the relationships K-Cd, Zn-Sr, Zn-F, THg-Pb, Pb-Cd, Se-Se/Pb, Se-Se/Cd, Se/Pb-Se/Cd, Pb-Cd/Ca, Cd-Cd/Ca, and F-F/Ca1000. Significant negative correlations were found for the relationships THg-Se/Pb, Pb-Se/Pb, Cd-Se/Pb, K-Se/Cd, Pb-Se/Cd, Cd-Se/Cd, THg-Se/THg, Pb-Se/THg, Se-Pb/Cd, Zn-Cd/Ca, and Se/Cd-Cd/Ca. The results reported here may provide a basis for establishing reference values for the tibial plateau in patients with OA who had undergone knee replacement surgery. The concentrations of elements in the bone with OA were determined by age, presence of implants, smoking, fish and seafood diet, and sport activity.