Review Article

Modulation of Immunity and Inflammation by the Mineralocorticoid Receptor and Aldosterone

Figure 2

Immunological effect of MR antagonism and knockout. In vitro treatment with pharmacological antagonist of MR has suggested that this receptor could be important to keep immune function, because its antagonism directly modulates the proinflammatory cytokines and chemokines production and cell migration. These results also have been reported in other cell types such as adipocytes, which today are known as a source of inflammatory mediators. In animal models the treatment with MR antagonist or KO animals to myeloid MR has supported the notion of MR as immune regulator.