Ring-Oxidative Biotransformation and Drug Interactions of Propofol in the Livers of Rats

Figure 2

Identification of 4-hydroxypropofol. After reacting propofol with control or phenobarbital (PB)-treated liver microsomes in an NADPH-generation system, the metabolites were extracted with cyclohexane and dried with nitrogen gas. The extracted metabolites were dissolved in a mobile phase for analyses by liquid chromatography ((a), (b), left panes) and mass spectroscopy ((a), (b), right panels).

(a)

(b)