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BioMed Research International
Volume 2015, Article ID 671349, 9 pages
http://dx.doi.org/10.1155/2015/671349
Research Article

On the Estimation of Heritability with Family-Based and Population-Based Samples

1The Center for Genome Science, Korea National Institute of Health, KCDC, Osong 361-951, Republic of Korea
2Department of Applied Statistics, Chung-Ang University, Seoul 156-756, Republic of Korea
3Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 151-742, Republic of Korea
4Chunlab Inc., Seoul National University, Seoul 151-742, Republic of Korea
5Department of Epidemiology, Seoul National University, Seoul 151-742, Republic of Korea
6Department of Preventive Medicine, Ajou University School of Medicine, Suwon 443-380, Republic of Korea
7Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106-7281, USA
8Department of Epidemiology and Biostatistics, School of Public Health & Institute of Health and Environment, Seoul National University, Seoul 151-742, Republic of Korea

Received 22 November 2014; Revised 16 April 2015; Accepted 21 April 2015

Academic Editor: Kristel van Steen

Copyright © 2015 Youngdoe Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table S1: presents correlations between Type 2 diabetes status and various traits related to cardiovascular disease in the KARE cohort. Supplementary Tables S2-S9: contain heritability estimates for height, BMI, log(TG), TCHL, HDL, LDL, SBP and DBP. Heritability in three Korean populations was estimated with S.A.G.E. and GCTA, and variance-covariance matrices for their linear mixed models were parameterized with FRM and GRM respectively. Supplementary Table S10: presents missing rates for height, BMI, log(TG), TCHL, HDL, LDL, SBP and DBP in each cohort. Supplementary Table S11: contain correlations between family members. The mother-father, parent-offspring and sibling correlations, and their 95% confidence intervals were estimated. Supplementary Figures S1-S2: present Q-Q plots for height, BMI, log(TG), TCHL, HDL, LDL, SBP and DBP in each cohort. Supplementary Figures S3-S6: present heritability estimates for various levels of genetic correlation with 10,000 individuals when heritability was assumed to be 0.1, 0.3, 0.7, or 0.9.

  1. Supplementary Material