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BioMed Research International
Volume 2015, Article ID 672520, 9 pages
Research Article

Enhanced Classification of Interstitial Lung Disease Patterns in HRCT Images Using Differential Lacunarity

1INESC TEC, Campus da FEUP, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
2Coimbra Institute of Engineering, Polytechnic Institute of Coimbra, Rua Pedro Nunes, Quinta da Nora, 3030-199 Coimbra, Portugal
3School of Science and Technology, University of Trás-os-Montes e Alto Douro, Apartado 1013, 5001-801 Vila Real, Portugal
4Military Academy Research Center, Avenida Conde Castro Guimarães, 2720-113 Amadora, Portugal

Received 11 September 2015; Accepted 18 November 2015

Academic Editor: Yukihisa Takayama

Copyright © 2015 Verónica Vasconcelos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The analysis and interpretation of high-resolution computed tomography (HRCT) images of the chest in the presence of interstitial lung disease (ILD) is a time-consuming task which requires experience. In this paper, a computer-aided diagnosis (CAD) scheme is proposed to assist radiologists in the differentiation of lung patterns associated with ILD and healthy lung parenchyma. Regions of interest were described by a set of texture attributes extracted using differential lacunarity (DLac) and classical methods of statistical texture analysis. The proposed strategy to compute DLac allowed a multiscale texture analysis, while maintaining sensitivity to small details. Support Vector Machines were employed to distinguish between lung patterns. Training and model selection were performed over a stratified 10-fold cross-validation (CV). Dimensional reduction was made based on stepwise regression (-test, value < 0.01) during CV. An accuracy of 95.8 ± 2.2% in the differentiation of normal lung pattern from ILD patterns and an overall accuracy of 94.5 ± 2.1% in a multiclass scenario revealed the potential of the proposed CAD in clinical practice. Experimental results showed that the performance of the CAD was improved by combining multiscale DLac with classical statistical texture analysis.