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BioMed Research International
Volume 2015 (2015), Article ID 674039, 7 pages
http://dx.doi.org/10.1155/2015/674039
Research Article

Genetic Variations in Inflammatory Response Genes and Their Association with the Risk of Prostate Cancer

Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

Received 1 April 2015; Revised 25 May 2015; Accepted 10 June 2015

Academic Editor: Sabine Rohrmann

Copyright © 2015 Xin Cui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Prostate cancer is a common cancer in men. Genetic variations in inflammatory response genes can potentially influence the risk of prostate cancer. We aimed to examine the association between PPARG Pro12Ala, NFKB1 -94 ins/del, NFKBIA -826C/T, COX-1 (50C>T), and COX-2 (-1195G>A) polymorphisms on prostate cancer risk. The genotypes of the polymorphisms were ascertained in 543 prostate cancer patients and 753 controls through PCR-RFLP and the risk association was evaluated statistically using logistic regression analysis. The NFKB1 -94 polymorphism was shown to decrease prostate cancer risk in both heterozygous and homozygous comparison models (odds ratios of 0.74 (95% CI = 0.58–0.96) () and 0.57 (95% CI = 0.42–0.78) (), resp.). An opposite finding was observed for COX-2 (-1195) polymorphism (odds ratios of 1.58 (95% CI = 1.15–2.18) () for heterozygous comparison model and 2.08 (95% CI = 1.48–2.92) () for homozygous comparison model). No association was observed for other polymorphisms. In conclusion, NFKB1 -94 ins/del and COX-2 (-1195G>A) polymorphisms may be, respectively, associated with decreased and increased prostate cancer risk in the Chinese population.