Noncoding RNAs, Emerging Regulators of Skeletal Muscle Development and Diseases

Figure 1

miRNAs in myogenesis. The diagram shows various miRNAs and targets that regulate the quiescence and activation of satellite cells, proliferation of myoblasts, and their subsequent cell cycle exit and terminal differentiation into myofibers. The myogenic transcription factors play a central role by governing the expression of several muscle-enriched miRNAs such as miR-1, miR-206, and miR-133 (magenta). The myogenic transcription factors characteristic of each stage of the myogenic process are marked in corresponding colors in a black box. The listed targets include paired box genes 3 and 7 (Pax3 and Pax7), serum response factor (SRF), DNA polymerase catalytic subunit (DNA polα), cell-division cycle protein 25A (Cdc25A), homeobox A11 (HoxA11), Yin and Yang 1 (YY1), enhancer of zeste homolog 2 (Ezh2), histone deacetylase 4 (HDAC4), insulin-like growth factor (IGF), uncoupling protein 2 (UCP2), and PR domain containing 16 (PRDM16).