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BioMed Research International
Volume 2015 (2015), Article ID 678924, 12 pages
http://dx.doi.org/10.1155/2015/678924
Research Article

The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients

1Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, Qatar
2Cardiology Unit, Ahmed Maher Teaching Hospital, Cairo, Egypt
3Clinical Medicine, Weill Cornell Medical School, P.O. Box 24144, Doha, Qatar
4Cardiology Unit, Al-Emadi Hospital, P.O. Box 5804, Doha, Qatar
5Clinical Chemistry Department, Hamad Medical Corporation (HMC), P.O. Box 3050, Doha, Qatar
6Cardiology Department, Heart Hospital, Hamad Medical Corporation (HMC), P.O. Box 3050, Doha, Qatar

Received 16 July 2014; Revised 5 November 2014; Accepted 29 December 2014

Academic Editor: Kosmas Paraskevas

Copyright © 2015 Nasser M. Rizk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Several polymorphisms of a locus on chromosome 1p13.3 have a significant effect on low-density lipoprotein cholesterol (LDL-C), atherosclerosis, and acute coronary syndrome (ACS). Methods. We aimed to investigate the association between rs599839, rs646776, and rs4970834 of locus 1p13.3 and serum LDL-C and severity of coronary artery stenosis in ACS patients. Genotyping of the rs599839, rs646776, and rs4970834 polymorphisms was performed on Arab patients undergoing coronary angiography for ACS. Patients were divided into group A (ACS with insignificant stenosis (<50%)) and group B (with significant stenosis (≥50%)). Results. Patients carrying the minor G allele in rs599839 had significantly lower mean of LDL-C (2.58 versus 3.44 mM, ) than homozygous A allele carriers (GG versus AA). Carriers of minor C allele in rs64776 had significantly higher mean of HDL-C (2.16 versus 1.36 mM, ) than carriers of the T alleles (AA versus GG). The odd ratio and 95% confidence interval for dominant model for G allele carriers of rs599839 were 0.51 (0.30–0.92), , among patients with significant stenosis. Conclusions. Polymorphisms rs646776 and rs599839 of locus 1p13.3 were significantly associated with LDL-C and other lipid parameters. In addition, the G-allele carriers of variant rs599839 had a significant protective effect against the atherosclerosis.