The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients

Table 5

Results from logistic regression analysis: associations between determined SNPs and significant coronary stenosis for carriers of the rare allele compared to carriers of the homozygous common allele.

SNP	Model	OR	95% CI	value
rs599839	Model 1	0.59	0.34–0.97	0.049
	Model 2	0.56	0.32–0.94	0.043
	Model 3	0.51	0.30–0.92	0.038
rs646776	Model 1	0.62	0.27–1.43	0.263
	Model 2	0.55	0.21–1.46	0.227
	Model 3	0.53	0.19–1.45	0.213
rs4970834	Model 1	0.98	0.57–1.68	0.944
	Model 2	0.83	0.45–1.51	0.545
	Model 3	0.88	0.46–1.70	0.705

Three logistic regression models were built: model 1 remained unadjusted, model 2 adjusted for age, gender, obesity, hypertension, diabetes, smoking, and family history of CAD, and model 3 for the covariates adjusted in model 2 and additionally LDL, HDL, and statin. OR, odds ratio, and CI, confidence interval. Two-tailed value is significant at <0.05.