CD40 Ligand Deficient C57BL/6 Mouse Is a Potential Surrogate Model of Human X-Linked Hyper IgM (X-HIGM) Syndrome for Characterizing Immune Responses against Pathogens

Figure 5

C. rodentium-specific sera antibodies of wild type (WT) and C57-CD40L^−/− mice. Mice orally inoculated with CFU of C. rodentium were bled at day 14 after inoculation. Each point of these curves represents the mean ± SD of the OD determinations. (a) The specific IgM titres were essentially identical between the two groups. ((b) and (c)) The specific IgG and IgG2b titres were significantly lower for C57-CD40L^−/− mice than WT mice. (d) IgG2c specific antibodies of both WT and C57-CD40L^−/− mice were just above baseline and IgG1 and IgG3 isotypes were undetectable. Antibody titres are presented as means and data was analysed by Mann-Whitney -test. OD = optical density, (1 : ) = dilution factor.

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