Serial Patterns of Ovarian Cancer Biomarkers in a Prediagnosis Longitudinal Dataset

Table 3

AUC and 95% confidence intervals together with sensitivity level for specificity >0.9 for CA125 alone and the best marker combination using the last measurement for all subjects. A value is given for comparison of AUCs between the multimarker model and CA125 alone.

Model	AUC	95% CI	Diff. in AUCs ()	Sensitivity (specificity >0.9)
CA125	0.957	0.918–0.997	—	0.894
CA125 + HE4	0.965	0.935–0.995	0.008 (0.182)	0.894
CA125 + glycodelin + HE4	0.967	0.938–0.996	0.01 (0.206)	0.915