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BioMed Research International
Volume 2015 (2015), Article ID 684084, 9 pages
http://dx.doi.org/10.1155/2015/684084
Review Article

The Use of Stem Cells in Burn Wound Healing: A Review

1Faculty of Medicine, American University of Beirut, Beirut, Lebanon
2Department of Anatomy and Regenerative Biology, George Washington University, Washington, DC, USA
3Department of Surgery, American University of Beirut, Beirut, Lebanon
4Lebanese Health Society, Beirut, Lebanon
5Department of Anatomy, Cell Biology, and Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
6Eye Institute, National Institutes of Health, Bethesda, MD, USA

Received 3 November 2014; Revised 21 January 2015; Accepted 22 January 2015

Academic Editor: Cornelia Kasper

Copyright © 2015 Fadi Ghieh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Burn wound healing involves a series of complex processes which are subject to intensive investigations to improve the outcomes, in particular, the healing time and the quality of the scar. Burn injuries, especially severe ones, are proving to have devastating effects on the affected patients. Stem cells have been recently applied in the field to promote superior healing of the wounds. Not only have stem cells been shown to promote better and faster healing of the burn wounds, but also they have decreased the inflammation levels with less scar progression and fibrosis. This review aims to highlight the beneficial therapeutic effect of stem cells in burn wound healing and to discuss the involved pathways and signaling molecules. The review covers various types of burn wound healing like skin and corneal burns, along with the alternative recent therapies being studied in the field of burn wound healing. The current reflection of the attitudes of people regarding the use of stem cells in burn wound healing is also stated.