Volumetric MR-Guided High-Intensity Focused Ultrasound with Direct Skin Cooling for the Treatment of Symptomatic Uterine Fibroids: Proof-of-Concept Study

Table 2

Baseline characteristics and MRI findings ().

Patient characteristics
Age (years)^a	42.5 (38.8–47.8)
BMI (kg/m^2)^a	23.1 (19.9–28.1)
Symptoms^b
Menorrhagia	3 (38%)
Bulky symptoms	4 (50%)
Infertility	1 (12%)
tSSS^a	57.9 (38.3–79.0)
Total HRQoL^a	48.7 (28.9–80.4)
Lesion characteristics
Number of fibroids^b
Solitary fibroid	2 (25%)
Multiple fibroids	6 (75%)
2–5 fibroids	4 (67%)
6–10 fibroids	2 (33%)
Location of fibroids^b
Intramural	6 (67%)
Submucosal	3 (33%)
Type of fibroid^b
Type 1	4 (45%)
Type 2	3 (33%)
Type 3	2 (22%)
Maximum fibroid diameter (cm)^a	7.7 (5.1–8.8)
Uterine fibroid volume (cm^3)^a	147 (49–338)

Median (interquartile range); ^bnumber (percentage); MR-HIFU: MR-guided high-intensity focused ultrasound; tSSS: transformed symptom severity score (range 0–100); high scores indicate more severe symptoms; HRQoL: health-related quality of life (range 0–100); high scores indicate better quality of life; type 1: low signal intensity on T2-weighted imaging; type 2: intermediate signal intensity on T2-weighted imaging; type 3: high signal intensity on T2-weighted imaging; NPV: nonperfused volume.