Evaluation of Transduction Properties of an Adenovirus Vector in Neonatal Mice

Figure 1

Schematic diagrams of the replication-incompetent Ad vectors used in this study. A luciferase or murine secreted embryonic alkaline phosphatase (mSEAP) expression cassette was inserted into the E1-deleted region in the Ad vector genome. AHA, a synthetic promoter composed of an apolipoprotein E enhancer, the hepatocyte control region, and a human alpha1-antitrypsin promoter; CMV, cytomegalovirus promoter; ITR, inverted terminal repeat.