Evaluation of Transduction Properties of an Adenovirus Vector in Neonatal Mice

Figure 3

Ad vector-mediated toxicity in neonatal mice. (a, b) Serum ALT and AST levels in the neonatal mice following systemic administration of an Ad vector. Neonatal mice were administered Ad-AHAL2 at a dose of 5.9 × 10¹¹ IFU/kg via retro-orbital sinus. Serum samples were collected at the indicated time points. (c) Liver sections of neonatal mice following systemic administration of PBS (left) and an Ad vector (right). The livers were isolated 48 h after Ad vector administration. Scale bars represent 100 μm. (d) Serum CK levels in the neonatal mice following systemic administration of an Ad vector. Serum CK activity was measured 48 h after Ad-AHAL2 administration ( animals per group for a, b, and d and 2 for c).

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