Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines

Figure 4

(a) A low-grade prostate adenocarcinoma showing weak serglycin expression. (b) A high-grade prostate adenocarcinoma with strong cytoplasmic, diffuse immunoreactivity for serglycin. (c) Note that tumor, endothelial (arrow), and stroma cells are positive for serglycin in this high-grade prostate adenocarcinoma. (d) In this case of low-grade prostatic adenocarcinoma, malignant and benign prostate glands, as well as fibromuscular stroma (asterisk), display serglycin immunopositivity; on the contrary, basal cells of the benign prostate glands (arrow) are negative for this protein. (e) Benign prostate hyperplasia. Benign glands, stromal cells, chronic inflammation cells (plasma cells and lymphocytes), and corpora amylacea (asterisk) are serglycin-reactive. Also note that basal cells do not exhibit serglycin immunoreactivity. (f) In this section of normal prostate, epithelial cells and smooth muscle (asterisk) are positive, whereas fibrovascular core cells (arrow) are negative for serglycin. (a–e) Original magnification 20x; (f) original magnification 40x.

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