Dependence of Thyroid Sonographic Markers of Malignancy and Its Influence on the Diagnostic Value of Sonographic Findings

Table 3

Sensitivity, specificity, positive predictive value, and odds ratio for all possible panels composed of two markers of malignancy included in our study.

		Cancers possessing both features	Benignancies possessing both features	Sensitivity	Specificity	Positive predictive value	Relative risk
Hypoechogenicity	Taller than wide	6	15	0.27	0.96	0.29	6.75
Hypoechogenicity	Halo absence	20	210	0.91	0.43	0.09	1.61
Hypoechogenicity	Irregular margins	15	63	0.68	0.83	0.19	4.02
Hypoechogenicity	Mean stiffness ≥ 38 kPa	19	67	0.86	0.82	0.22	4.78
Hypoechogenicity	Solid character	18	152	0.82	0.59	0.11	2.00
Hypoechogenicity	Microcalcifications	9	51	0.41	0.86	0.15	2.98
Hypoechogenicity	Macrocalcifications	4	24	0.18	0.94	0.14	2.81
Taller than wide	Halo absence	6	25	0.27	0.93	0.19	4.05
Taller than wide	Irregular margins	5	8	0.23	0.98	0.38	10.54
Taller than wide	Mean stiffness ≥ 38 kPa	6	9	0.27	0.98	0.40	11.24
Taller than wide	Solid character	5	17	0.23	0.95	0.23	4.96
Taller than wide	Microcalcifications	3	8	0.14	0.98	0.27	6.32
Taller than wide	Macrocalcifications	0	6	0.00	0.98	0.00	0.00
Halo absence	Irregular margins	16	95	0.73	0.74	0.14	2.84
Halo absence	Mean stiffness ≥ 38 kPa	19	99	0.86	0.73	0.16	3.24
Halo absence	Solid character	18	181	0.82	0.51	0.09	1.68
Halo absence	Microcalcifications	10	61	0.45	0.84	0.14	2.76
Halo absence	Macrocalcifications	5	26	0.23	0.93	0.16	3.24
Irregular margins	Mean stiffness ≥ 38 kPa	15	35	0.68	0.91	0.30	7.23
Irregular margins	Solid character	15	53	0.68	0.86	0.22	4.77
Irregular margins	Microcalcifications	10	22	0.45	0.94	0.31	7.67
Irregular margins	Macrocalcifications	4	18	0.18	0.95	0.18	3.75
Mean stiffness ≥ 38 kPa	Solid character	17	60	0.77	0.84	0.22	4.78
Mean stiffness ≥ 38 kPa	Microcalcifications	9	33	0.41	0.91	0.21	4.60
Mean stiffness ≥ 38 kPa	Macrocalcifications	4	18	0.18	0.95	0.18	3.75
Solid character	Microcalcifications	9	35	0.41	0.91	0.20	4.34
Solid character	Macrocalcifications	3	18	0.14	0.95	0.14	2.81
Microcalcifications	Macrocalcifications	3	15	0.14	0.96	0.17	3.37