Multimodality MRI Findings in Patients with End-Stage Renal Disease

Figure 3

Significant altered brain regions with fractional anisotropy (FA) and mean diffusivity (MD) in hemodialysis ESRD patients compared with healthy controls. The background image is the standard MNI 152 brain template. Green voxels represent the white matter skeleton of FA. (a, c, and e) Blue voxels represent brain regions with reduced FA in hemodialysis ESRD patients (, FEW corrected). (a) Axial, (c) coronal, and (e) sagittal FA maps show the reduced FA regions are mainly located in the genu, splenium, and body of corpus callosum, bilateral anterior corona radiata, posterior corona radiata, superior corona radiata, and posterior thalamic radiation, left superior longitudinal fasciculus, and right cingulum. (b, d, and f) Red voxels represent brain regions with increased MD in hemodialysis ESRD patients (, FEW corrected). (b) Axial, (d) coronal, and (f) sagittal MD maps show the increased FA regions are located in almost all white matter regions and bilateral cerebellum, midbrain, and pons. FA: fractional anisotropy; MD: mean diffusivity; ESRD: end-stage renal disease; R: right; L: left.

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