High LIN28A Expressing Ovarian Cancer Cells Secrete Exosomes That Induce Invasion and Migration in HEK293 Cells

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Fold change</td><td align="center">Genes</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">25.65</td><td align="center">TIMP1 </td></tr><tr><td align="left">10.95</td><td align="center">FOXC2 </td></tr><tr><td align="left">10.55</td><td align="center">NOTCH1 </td></tr><tr><td align="left">9.67</td><td align="center">PTP4A1 </td></tr><tr><td align="left">8.32</td><td align="center">GNG11 </td></tr><tr><td align="left">7.37</td><td align="center">SNAI1 </td></tr><tr><td align="left">7.33</td><td align="center">FGFBP1 </td></tr><tr><td align="left">7.13</td><td align="center">SOX10 </td></tr><tr><td align="left">6.58</td><td align="center">COL3A1 </td></tr><tr><td align="left">6.49</td><td align="center">JAG1 </td></tr><tr><td align="left">6.45</td><td align="center">WNT5A </td></tr><tr><td align="left">6.41</td><td align="center">SNAI3 </td></tr><tr><td align="left">6.38</td><td align="center">NODAL </td></tr><tr><td align="left">6.35</td><td align="center">CDH1 </td></tr><tr><td align="left">6.32</td><td align="center">IL1RN </td></tr><tr><td align="left">6.04</td><td align="center">TMEM132A </td></tr><tr><td align="left">5.7</td><td align="center">COL1A2 </td></tr><tr><td align="left">5.53</td><td align="center">GSC </td></tr><tr><td align="left">5.39</td><td align="center">MMP3 </td></tr><tr><td align="left">5.35</td><td align="center">ERBB3 </td></tr><tr><td align="left">5.32</td><td align="center">SNAI2 </td></tr><tr><td align="left">5.24</td><td align="center">BMP1 </td></tr><tr><td align="left">5.2</td><td align="center">KRT7 </td></tr><tr><td align="left">5.15</td><td align="center">MST1R </td></tr><tr><td align="left">5.13</td><td align="center">PTK2 </td></tr><tr><td align="left">4.82</td><td align="center">F11R </td></tr><tr><td align="left">4.78</td><td align="center">AHNAK </td></tr><tr><td align="left">4.49</td><td align="center">IGFBP4 </td></tr><tr><td align="left">4.29</td><td align="center">FZD7 </td></tr><tr><td align="left">4.28</td><td align="center">TWIST1 </td></tr><tr><td align="left">4.19</td><td align="center">ITGA5 </td></tr><tr><td align="left">4.14</td><td align="center">WNT5B </td></tr><tr><td align="left">4.12</td><td align="center">STAT3 </td></tr><tr><td align="left">4.09</td><td align="center">BMP7 </td></tr><tr><td align="left">4</td><td align="center">MMP9 </td></tr><tr><td align="left">3.95</td><td align="center">SPP1 </td></tr><tr><td align="left">3.86</td><td align="center">SPARC </td></tr><tr><td align="left">3.82</td><td align="center">SERPINE1 </td></tr><tr><td align="left">3.81</td><td align="center">ILK </td></tr><tr><td align="left">3.8</td><td align="center">PLEK2 </td></tr><tr><td align="left">3.37</td><td align="center">WNT11 </td></tr><tr><td align="left">3.25</td><td align="center">TMEFF1 </td></tr><tr><td align="left">3.22</td><td align="center">TGFB1 </td></tr><tr><td align="left">3.09</td><td align="center">TGFB3 </td></tr><tr><td align="left">3.03</td><td align="center">ZEB1 </td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Epithelial-to-Mesenchymal Transition (EMT) related genes that are significantly upregulated after HEK293 cells exposed to IGROV1 cell-secreted exosomes.

BioMed Research International

tab2

Table 2

Table 2: High LIN28A Expressing Ovarian Cancer Cells Secrete Exosomes That Induce Invasion and Migration in HEK293 Cells 