Protective Effects of Cilastatin against Vancomycin-Induced Nephrotoxicity

Table 1

In vitro activity of vancomycin alone and with cilastatin against clinical isolates of Staphylococcus aureus and Enterococcus spp.

	Strain 1		Strain 2		Strain 3		Strain 4
Staphylococcus aureus	Vehicle	Cil	Vehicle	Cil	Vehicle	Cil	Vehicle	Cil
MIC	0.5	1	0.5	1	1	0.5	0.5	0.5
MBC	16	32	2	2	1	0.5	0.5	0.5
	Strain 5		Strain 6		Strain 7		Strain 8
Enterococcus spp.	Vehicle	Cil	Vehicle	Cil	Vehicle	Cil	Vehicle	Cil
MIC	0.5	0.5	0.25	0.5	1	2	0.5	0.5
MBC	>16	>16	>4	>8	>16	>32	>8	>8

Table shows the effect of cilastatin (200 g/mL) against inhibitory and bactericidal activity of vancomycin (0–64 g/mL) in clinical bacteria isolated. Staphylococcus aureus: strains numbers 1 and 4, methicillin-resistant; strain numbers 2 and 3, methicillin-susceptible. Enterococcus spp.: strains numbers 5, 7, and 8, E. faecalis; strain number 6, E. faecium.
MIC, minimum inhibitory concentration; MBC, minimum bactericidal concentration; vehicle, cation-adjusted Mueller-Hinton broth; cil, cilastatin.