BioMed Research International / 2015 / Article / Tab 1

Research Article

Protective Effects of Cilastatin against Vancomycin-Induced Nephrotoxicity

Table 1

In vitro activity of vancomycin alone and with cilastatin against clinical isolates of Staphylococcus aureus and Enterococcus spp.

Strain 1Strain 2Strain 3Strain 4

Staphylococcus aureus VehicleCilVehicleCilVehicleCilVehicleCil
MIC0.510.5110.50.50.5

MBC16322210.50.50.5

Strain 5Strain 6Strain 7Strain 8

Enterococcus spp.VehicleCilVehicleCilVehicleCilVehicleCil
MIC0.50.50.250.5120.50.5

MBC>16>16>4>8>16>32>8>8

Table shows the effect of cilastatin (200 g/mL) against inhibitory and bactericidal activity of vancomycin (0–64 g/mL) in clinical bacteria isolated. Staphylococcus aureus: strains numbers 1 and 4, methicillin-resistant; strain numbers 2 and 3, methicillin-susceptible. Enterococcus spp.: strains numbers 5, 7, and 8, E. faecalis; strain number 6, E. faecium.
MIC, minimum inhibitory concentration; MBC, minimum bactericidal concentration; vehicle, cation-adjusted Mueller-Hinton broth; cil, cilastatin.